TRIB3 Human
目录号 : GP22645Tribbles Pseudokinase 3 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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TRIB3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 381 amino acids (1-358 a.a) andhaving a molecular mass of 42.0kDa.TRIB3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Cell Growth Regulator With EF-Hand Domain 1; Cell GrowthRegulatory Gene 11 Protein; Hydrophobestin; CGR11; Cell Growth Regulator WithEF Hand Domain Protein 1; Cell Growth Regulator With EF Hand Domain 1; Tribbleshomolog 3. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMRATPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCLLPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPHKHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCRFVFADRERKK LVLENLEDSC VLTGPDDSLW DKHACPAYVG PEILSSRASY SGKAADVWSL GVALFTMLAGHYPFQDSEPV LLFGKIRRGA YALPAGLSAP ARCLVRCLLR REPAERLTAT GILLHPWLRQ DPMPLAPTRSHLWEAAQVVP DGLGLDEARE EEGDREVVLY G. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | TRIB3 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH8.0) and 10% glycerol. | ||
Tribbles Pseudokinase 3, also known as TRIB3, is a putative proteinkinase which is induced by the transcription factor NF-kappaB. In addition,TRIB3 is a negative regulator of NF-kappaB, and can as well sensitize cells toTNF- and TRAIL-induced apoptosis. Furthermore, TRIB3 is able to negativelyregulate the cell survival serine-threonine kinase AKT1. One of the diseaseswhich are associated with TRIB3 is anoxia.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.