Trichlormethine hydrochloride (Tris(2-chloroethyl)amine hydrochloride)
(Synonyms: 三(2-氯乙基)胺盐酸盐) 目录号 : GC33069
Trichlormethinehydrochloride是治疗癌症和关节炎的细胞生长抑制剂;对人类有致癌作用。
Cas No.:817-09-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Trichlormethine hydrochloride is a cytostatic agent in the treatment of cancer and arthritis; shows carcinogenic effects to humans.
Trichlormethine could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m2/g. TEA, the exhaustive hydrolysis product of trichlormethine, is detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm[1].
Trichlormethine hydrochloride carries a genetic risk for the postmeiotic stages of spermatogenesis and is responsible for interference in the morphology of sperm heads through its action on spermatocytes. The toxic effects of trichlormethine hydrochloride are found to influence the body weight of mice, to reduce the relative weight of the testes, to damage spermatogenesis in the seminiferous tubules, to be responsible for an appearance of multinucleate cells in the epididymides, and for an increased rate of abnormality of the heads of fully mature spermatozoa[2].
[1]. Gresham GL, et al. Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. J Mass Spectrom. 2000 Dec;35(12):1460-9. [2]. S?kora I, et al. Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice. Mutat Res. 1992 Apr;266(2):291-7.
| Cas No. | 817-09-4 | SDF | |
| 别名 | 三(2-氯乙基)胺盐酸盐 | ||
| Canonical SMILES | ClCCN(CCCl)CCCl.Cl | ||
| 分子式 | C6H13Cl4N | 分子量 | 240.99 |
| 溶解度 | DMSO : 100 mg/mL (414.95 mM);Water : 50 mg/mL (207.48 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1495 mL | 20.7477 mL | 41.4955 mL |
| 5 mM | 0.8299 mL | 4.1495 mL | 8.2991 mL |
| 10 mM | 0.415 mL | 2.0748 mL | 4.1495 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。