Trichloroacetic acid
(Synonyms: 三氯乙酸) 目录号 : GC64050
Trichloroacetic acid 是一种常用的面部表面修复剂。Trichloroacetic acid 是三氯乙烯的代谢产物，被认为有助于其在小鼠体内的肝癌效应。
Cas No.:76-03-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Trichloroacetic acid is a commonly utilized agent for chemical resurfacing of the face. Trichloroacetic acid is a metabolite of trichloroethylene thought to contribute to its hepatocarcinogenic effects in mice[1][2].
Trichloroacetic acid (TCA) is a common drinking water disinfection byproduct that produces a spectrum of liver effects, including hepatomegaly and liver tumors, in mice. It is also an oxidative metabolite of trichloroethylene (TCE), a solvent used in degreasing with widespread environmental exposure, which also produces hepatomegaly and liver tumors in mice[3].
[1]. Herbig K, et al. Combination Jessner’s solution and trichloroacetic acid chemical peel: technique and outcomes. Plast Reconstr Surg. 2009;124(3):955-964.
[2]. Stenner RD, et al. Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene. Drug Metab Dispos. 1997;25(5):529-535.
[3]. Chiu WA. Trichloroacetic acid: updated estimates of its bioavailability and its contribution to trichloroethylene-induced mouse hepatomegaly. Toxicology. 2011;285(3):114-125.
| Cas No. | 76-03-9 | SDF | Download SDF |
| 别名 | 三氯乙酸 | ||
| 分子式 | C2HCl3O2 | 分子量 | 163.39 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.1203 mL | 30.6016 mL | 61.2033 mL |
| 5 mM | 1.2241 mL | 6.1203 mL | 12.2407 mL |
| 10 mM | 0.612 mL | 3.0602 mL | 6.1203 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Trichloroacetic acid peels revisited
J Dermatol Surg Oncol 1989 Sep;15(9):933-40.PMID:2674238DOI:10.1111/j.1524-4725.1989.tb03180.x.
Trichloroacetic acid (TCA) is a time-honored peeling agent that has no known systemic toxicity. Recent interest in reversing the effects of actinic damage has led to the utilization of combination therapies. Retinoic acid, solid CO2, pyruvic acid, Jessner's formula, and other agents have been used to increase the effectiveness of TCA and enhance peeling results. Repetitive peels with low concentrations of TCA can be effective for areas prone to scarring.
Trichloroacetic acid in the environment
Chemosphere 2002 May;47(7):667-86.PMID:12079062DOI:10.1016/s0045-6535(01)00343-5.
Suppositions that the Trichloroacetic acid (TCA, CCl3C(O)OH) found in nature was a consequence solely of the use of chlorinated hydrocarbon solvents prompted this critical review of the literature on its environmental fluxes and occurrences. TCA is widely distributed in forest soils (where it was rarely used as an herbicide) and measurements suggest a soil flux of 160 000 tonnes yr(-1) in European forests alone. TCA is also produced during oxidative water treatment and the global flux could amount to 55 000 tonnes yr(-1) (from pulp and paper manufacture, potable water and cooling water treatments). By contrast, the yields of TCA from chlorinated hydrocarbon solvents are small: from tetrachloroethene 13 600 tonnes yr(-1) and from 1,1,1-trichloroethane 4300 tonnes yr(-1) on a global basis, at the atmospheric burdens and removal rates typical of the late 1990s. TCA is ubiquitous in rainwater and snow. Its concentrations are highly variable and the variations cannot be connected with location or date. However, there is no significant difference between the concentrations found in Chile and in eastern Canada (by the same analysts), or between Malawi and western Canada, or between Antarctica and Switzerland, nor any significant difference globally between the concentrations in cloud, rain and snow (although local enhancement in fog water has been shown). TCA is present in old ice and firn. At the deepest levels, the firn was deposited early in the 19th century, well before the possibility of contamination by industrial production of reactive chlorine, implying a non-industrial background. This proposition is supported by plume measurements from pulp mills in Finland. TCA is ubiquitous in soils; concentrations are very variable but there are some indications that soils under coniferous trees contain higher amounts. The concentrations of TCA found in plant tissue are region-specific and may also be plant-specific, to the extent that conifers seem to contain more than other species. TCA is removed from the environment naturally. There is abundant evidence that soil microorganisms dehalogenate TCA and it is lost from within spruce needles with a half-life of 10 days. There is also recent evidence of an abiotic aqueous decarboxylation mechanism with a half-life of 22 days. The supposedly widespread effects of TCA in conifer needles are not shown in controlled experiments. At concentrations in the needles of Scots pine similar to those observed in needles in forest trees, changes consequent on TCA treatment of field laboratory specimens were almost all insignificant.
Trichloroacetic acid (50%) in the treatment of venous leg ulcers
J Med Vasc 2021 May;46(3):139-143.PMID:33990288DOI:10.1016/j.jdmv.2021.03.006.
Introduction: Leg ulcers are a chronic and disabling condition that is difficult, time-consuming and costly to treat. We report a study evaluating the efficacy of Trichloroacetic acid in the treatment of venous leg ulcers. Patients and methods: We treated 19 patients with leg ulcers with 50% Trichloroacetic acid with one application per week for 6 weeks. The primary evaluation criteria was healing, assessed by measuring the surface area of the ulcer before and after treatment. Results: We included 13 men and 6 women, with venous leg ulcers, with an average age of 57 years. The mean ulcer duration was 2.9 years. Complete healing was achieved in 2 patients, good healing in 9 patients, moderate healing in 6 patients, and poor healing in 2 patients. Discussion: Our study supports the data in the literature from two published series, and suggests that 50% Trichloroacetic acid would be a good therapeutic alternative with satisfactory wound healing, low cost, and absence of adverse effects.
TCA precipitation
Methods Enzymol 2014;541:3-10.PMID:24674058DOI:10.1016/B978-0-12-420119-4.00001-X.
Trichloroacetic acid (TCA) precipitation of proteins is commonly used to concentrate protein samples or remove contaminants, including salts and detergents, prior to downstream applications such as SDS-PAGE or 2D-gels. TCA precipitation denatures the protein, so it should not be used if the protein must remain in its folded state (e.g., if you want to measure a biochemical activity of the protein).
Trichloroacetic acid in Different Concentrations: A Promising Treatment Modality for Vitiligo
Dermatol Surg 2021 Feb 1;47(2):e53-e57.PMID:32826599DOI:10.1097/DSS.0000000000002736.
Background: Despite the recent advances in the treatment of vitiligo, results are still largely unsatisfactory and many patients show either weak or no response to treatment. Few clinical trials have investigated the use of Trichloroacetic acid (TCA) to induce repigmentation in stable vitiligo. Objective: To evaluate the efficacy and safety of TCA, in different concentrations, for the treatment of stable localized vitiligo. Methods: The study included 100 patients with acral/nonacral stable vitiligo. Trichloroacetic acid was applied, as a monotherapy, to the vitiliginous patches at different concentrations according to the treated site every 2 weeks until complete repigmentation or for a maximum of 6 treatment sessions. Follow-up was done every month for 6 months to detect any recurrence. Results: Eyelid vitiligo showed the highest response to TCA treatment (excellent response in 80% of cases), followed by the face, trunk, and extremities. Lower response rates were noticed in the hands and feet vitiligo. Adverse effects were transient and insignificant in few patients. Conclusion: Trichloroacetic acid seems to be a potential, cost-effective, well-tolerated therapeutic option for the treatment of vitiligo in the adults and pediatric populations.