Triflupromazine hydrochloride
(Synonyms: 盐酸三氟丙嗪) 目录号 : GC30790
A phenothiazine with diverse biological activities
Cas No.:1098-60-8
Sample solution is provided at 25 µL, 10mM.
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Triflupromazine is a phenothiazine with diverse biological activities.1,2,3,4 It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).1 Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).2 It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.3 Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.4 Formulations containing triflupromazine were previously used as antipsychotics.
1.Snyder, S.H., Greenberg, D., and Yamumura, H.I.Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effectsJ. Psychiatr. Res.1191-95(1974) 2.Tuomisto, J.A new modification for studying 5-HT uptake by blood platelets: A re-evaluation of tricyclic antidepressants as uptake inhibitorsJ. Pharm. Pharmacol.26(2)92-100(1974) 3.De Castro, S.L., Soeiro, M.N., and De Meirelles Mde, N.Trypanosoma cruzi: Effect of phenothiazines on the parasite and its interaction with host cellsMem. Inst. Oswaldo Cruz87(2)209-215(1992) 4.Dastidar, S.G., Debnath, S., Mazumdar, K., et al.Triflupromazine: A microbicide non-antibiotic compoundActa Microbiol. Immuno. Hung.51(1-2)75-83(2004)
| Cas No. | 1098-60-8 | SDF | |
| 别名 | 盐酸三氟丙嗪 | ||
| Canonical SMILES | FC(C(C=C1N2CCCN(C)C)=CC=C1SC3=C2C=CC=C3)(F)F.[H]Cl | ||
| 分子式 | C18H20ClF3N2S | 分子量 | 388.88 |
| 溶解度 | DMSO : ≥ 27 mg/mL (69.43 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5715 mL | 12.8574 mL | 25.7149 mL |
| 5 mM | 0.5143 mL | 2.5715 mL | 5.143 mL |
| 10 mM | 0.2571 mL | 1.2857 mL | 2.5715 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet