Triflupromazine hydrochloride
(Synonyms: 盐酸三氟丙嗪) 目录号 : GC30790
A phenothiazine with diverse biological activities
Cas No.:1098-60-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Triflupromazine is a phenothiazine with diverse biological activities.1,2,3,4 It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).1 Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).2 It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.3 Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.4 Formulations containing triflupromazine were previously used as antipsychotics.
1.Snyder, S.H., Greenberg, D., and Yamumura, H.I.Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effectsJ. Psychiatr. Res.1191-95(1974) 2.Tuomisto, J.A new modification for studying 5-HT uptake by blood platelets: A re-evaluation of tricyclic antidepressants as uptake inhibitorsJ. Pharm. Pharmacol.26(2)92-100(1974) 3.De Castro, S.L., Soeiro, M.N., and De Meirelles Mde, N.Trypanosoma cruzi: Effect of phenothiazines on the parasite and its interaction with host cellsMem. Inst. Oswaldo Cruz87(2)209-215(1992) 4.Dastidar, S.G., Debnath, S., Mazumdar, K., et al.Triflupromazine: A microbicide non-antibiotic compoundActa Microbiol. Immuno. Hung.51(1-2)75-83(2004)
| Cas No. | 1098-60-8 | SDF | |
| 别名 | 盐酸三氟丙嗪 | ||
| Canonical SMILES | FC(C(C=C1N2CCCN(C)C)=CC=C1SC3=C2C=CC=C3)(F)F.[H]Cl | ||
| 分子式 | C18H20ClF3N2S | 分子量 | 388.88 |
| 溶解度 | DMSO : ≥ 27 mg/mL (69.43 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5715 mL | 12.8574 mL | 25.7149 mL |
| 5 mM | 0.5143 mL | 2.5715 mL | 5.143 mL |
| 10 mM | 0.2571 mL | 1.2857 mL | 2.5715 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
TRIFLUPROMAZINE hydrochloride
Treatment of postalcoholic syndrome with triflupromazine hydrochloride
Comparative short-term evaluation of triflupromazine hydrochloride, chlorpromazine hydrochloride, and placebo in acutely disturbed patients
Triflupromazine Hydrochloride (Vesprin(R)) Its Value in Eye Surgery
Solubility and pKa determination of six structurally related phenothiazines
Solubilities of six structurally related phenothiazines, namely chlorpromazine hydrochloride, fluphenazine dihydrochloride, promazine hydrochloride, thioridazine hydrochloride, trifluoperazine dihydrochloride, and triflupromazine hydrochloride at constant pH were measured in the temperature range from 290 K to 350 K in three important drugs solvents: water, ethanol and 1-octanol using the dynamic method and UV-vis method. Dissociation constants and corresponding pK(a) values of drugs were obtained with Bates-Schwarzenbach method at temperature 298.15K in the buffer solutions. Our experimental pK(a) values for chlorpromazine hydrochloride, fluphenazine dihydrochloride, promazine hydrochloride, thioridazine hydrochloride, trifluoperazine dihydrochloride, and triflupromazine hydrochloride are 9.15, 10.01, 9.37, 8.89, 8.97, and 9.03, respectively. The basic thermal properties of pure drugs i.e. melting and solid-solid phase transition as well as glass-transition temperatures, the enthalpy of melting and phase transitions and the molar heat capacity at glass transition (at constant pressure) were measured with differential scanning microcalorimetry (DSC) technique. Molar volumes were calculated with Barton group contribution method. The experimental solubility data were correlated by means of three commonly known G(E) equations: the Wilson, NRTL and UNIQUAC with the assumption that the systems studied here have revealed simple eutectic mixtures. The root-mean-square deviations of temperature were used for the precision of the correlation. The activity coefficients of drugs at saturated solutions in each correlated binary mixture were calculated from the experimental data. These new data will help in all prediction-methods and their precision.