Home>>Signaling Pathways>> Neuroscience>> Behavioral Neuroscience>>Trimipramine-d3 (maleate)

Trimipramine-d3 (maleate) Sale

(Synonyms: 马来酸三甲丙咪嗪 d3 (马来酸盐)) 目录号 : GC48550

An internal standard for the quantification of trimipramine by GC- or LC-MS

Trimipramine-d3 (maleate) Chemical Structure

规格 价格 库存 购买数量
500µg
¥1,181.00
现货
1mg
¥2,125.00
现货
5mg
¥9,456.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

Trimipramine-d3 (maleate) is intended for use as an internal standard for the quantification of trimipramine (maleate) by GC- or LC-MS. Trimipramine is a tricyclic antidepressant.1,2,3 It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT; Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine H1 over H2, H3, and H4 receptors (Kis = 0.04, >100, and 43.6 µM, respectively).1,2 Trimipramine binds to muscarinic acetylcholine and α1- and α2-adrenergic receptors (Kds = 58, 24, and 580 nM, respectively), as well as dopamine D1 and D2 receptors and 5-HT receptor subtypes 5-HT1C and 5-HT2 (Kis = 346.7, 57.5, 537, and 19.5 nM, respectively).1,3 It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg.4 Formulations containing trimipramine have previously been used in the treatment of depression.

1.Richelson, E., and Nelson, A.Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitroJ. Pharmacol. Exp. Ther.230(1)94-102(1984) 2.Appl, H., Holzammer, T., Dove, S., et al.Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychoticsNaunyn-Schmiedebergs Arch. Pharmacol.385(2)145-170(2012) 3.Gross, G., Xin, X., and Gastpar, M.Trimipramine: Pharmacological reevaluation and comparison with clozapineNeuropharmacology30(11)1159-1166(1991) 4.Delini-Stula, A., Radeke, E., and van Riezen, H.Enhanced functional responsiveness of the dopaminergic system-the mechanism of anti-immobility effects of antidepressants in the behavioural despair test in the ratNeuropharmacology27(9)943-947(1988)

Chemical Properties

Cas No. SDF
别名 马来酸三甲丙咪嗪 d3 (马来酸盐)
Canonical SMILES CN(C([2H])([2H])[2H])CC(C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.OC(/C=C\C(O)=O)=O
分子式 C20H23D3N2•C4H4O4 分子量 413.5
溶解度 DMSO: soluble,Methanol: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.4184 mL 12.0919 mL 24.1838 mL
5 mM 0.4837 mL 2.4184 mL 4.8368 mL
10 mM 0.2418 mL 1.2092 mL 2.4184 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置