UBE2R2 Human
目录号 : GP22366Ubiquitin Conjugating Enzyme E2R 2 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | CDC34B; E2-CDC34B; UBC3B; Ubiquitin carrier protein R2; Ubiquitin-conjugatingenzyme E2-CDC34B; Ubiquitin-protein ligase R2; Ubiquitin-conjugating enzyme E2R2; EC 6.3.2.19. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMAQQQMT SSQKALMLEL KSLQEEPVEG FRITLVDESD LYNWEVAIFGPPNTLYEGGY FKAHIKFPID YPYSPPTFRF LTKMWHPNIY ENGDVCISIL HPPVDDPQSG ELPSERWNPTQNVRTILLSV ISLLNEPNTF SPANVDASVM FRKWRDSKGK DKEYAEIIRK QVSATKAEAE KDGVKVPTTL AEYCIKTKVP SNDNSSDLLYDDLYDDDIDD EDEEEEDADC YDDDDSGNEE S | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | UBE2R2 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. | ||
Ubiquitin-conjugatingenzyme E2 R2 (UBE2R2) is a member of the ubiquitin-conjugatingenzyme family. Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thrprotein kinase implicated in cell growth and transformation. This protein is a protein similar to theE2 ubiquitin conjugating enzymeUBC3/CDC34. Studies proposethat CK2-dependent phosphorylation of this ubiquitin-conjugating enzymefunctions by regulating beta-TrCPsubstrate recognition and induces itsinteraction with beta-TrCP, enhancing beta-catenin degradation. UBE2R2 receives ubiquitin from the E1complex and catalyzes its covalent attachment to other proteins. In vitro catalyzesmonoubiquitination and 'Lys-48'-linked polyubiquitination. UBE2R2 may be implicatedin degradation of katenin. Among the diseases associated with UBE2R2 are cblc,and herpes simplex.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.