UNG E.Coli
目录号 : GP22388Uracil DNA Glycosylase E.Coli Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | UDG; b2580; JW2564; EC 3.2.2.27; DGU; UNG15; HIGM5; Uracil-DNA Glycosylase 1; EC 3.2.2; HIGM4; UNG2. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMANELTW HDVLAEEKQQ PYFLNTLQTV ASERQSGVTI YPPQKDVFNAFRFTELGDVK VVILGQDPYH GPGQAHGLAF SVRPGIAIPP SLLNMYKELE NTIPGFTRPN HGYLESWARQGVLLLNTVLT VRAGQAHSHA SLGWETFTDK VISLINQHRE GVVFLLWGSH AQKKGAIIDK QRHHVLKAPH PSPLSAHRGF FGCNHFVLANQWLEQRGETP IDWMPVLPAE SE | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | UNG protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH8.0) and 10% glycerol. | ||
UNG is a member of the Uracil-DNA glycosylase family. One of his functions is to preventmutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond andinitiating the base-excision repair (BER) pathway. Uracil bases are formed as a result of cytosinedeamination or misincorporation of dUMP residues. After a mutation is formed,the mutagenic threatof uracil propagates through any subsequent DNA replication steps. Among the diseases associated with UNG are: congenital rubella,and immunodeficiency with hyper igm type 4.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.