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Vedaprofen Sale

(Synonyms: 维达洛芬,,Quadrisol; CERM 10202; PM 150) 目录号 : GC45141

An NSAID used in animals

Vedaprofen Chemical Structure

Cas No.:71109-09-6

规格 价格 库存 购买数量
500μg
¥742.00
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1mg
¥1,120.00
现货
5mg
¥1,483.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Vedaprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine to combat pain, inflammation, and fever associated with acute and chronic musculoskeletal disorders in horses and dogs. In addition to inhibiting COX and reducing prostaglandin H2 synthesis, vedaprofen is reported to block the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair.

Chemical Properties

Cas No. 71109-09-6 SDF
别名 维达洛芬,,Quadrisol; CERM 10202; PM 150
Canonical SMILES CC(C(O)=O)C(C1=C2C=CC=C1)=CC=C2C3CCCCC3
分子式 C19H22O2 分子量 282.4
溶解度 DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5411 mL 17.7054 mL 35.4108 mL
5 mM 0.7082 mL 3.5411 mL 7.0822 mL
10 mM 0.3541 mL 1.7705 mL 3.5411 mL
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Research Update

The pharmacokinetics of Vedaprofen and its enantiomers in dogs after single and multiple dosing

J Vet Pharmacol Ther 2005 Jun;28(3):305-12.PMID:15953205DOI:10.1111/j.1365-2885.2005.00659.x.

Vedaprofen is a chiral nonsteroidal anti-inflammatory drug that has been developed as a gel formulation for oral administration to dogs and horses. The pharmacokinetics of Vedaprofen and its enantiomers were studied in beagle dogs after single (intravenous solution and oral gel) and multiple (oral gel) dosing at a dosage of 0.5 mg/kg body weight. Plasma concentrations of Vedaprofen and its enantiomers were analysed by HPLC. The plasma protein binding of Vedaprofen was studied by ultrafiltration. The absorption of Vedaprofen was rapid (tmax 0.63 +/- 0.14 h) and almost complete after oral administration (bioavailability 86 +/- 7%). The terminal half-lives after intravenous and oral administration, 16.8 +/- 2.2 and 12.7 +/- 1.7 h respectively, were of the same order of magnitude. Enantioselective analysis showed that the R(-) enantiomer predominated in plasma. The change in the plasma time course of the plasma R(-)/S(+) enantiomer concentration ratio over time was similar after single intravenous and oral dosing, with R(-)/S(+) ratios in the AUC of 1.7 +/- 0.5 and 1.9 +/- 0.2 respectively. Plasma protein binding of Vedaprofen and its enantiomers was high (> 99.5%). Vedaprofen is absorbed rapidly from the gastrointestinal tract, has a high bioavailability and does not accumulate in plasma in dogs following repeated oral administration.

Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy

J Small Anim Pract 2007 Feb;48(2):70-5.PMID:17286658DOI:10.1111/j.1748-5827.2006.00211.x.

Objectives: The antipyretic and analgesic efficacy of Vedaprofen (at a dose of 0.5 mg/kg) was evaluated after repeated once-daily administration (for three or five days) to 80 cats with upper respiratory tract disease or 302 cats undergoing ovariohysterectomy. Methods: Both clinical trials were randomised, double blinded and placebo controlled. Results: In the upper respiratory tract disease trial, Vedaprofen produced a significant reduction in rectal temperature when compared with cats administered antimicrobial treatment only. This antipyretic activity lasted at least four hours after administration on the first day of treatment (day 0) and at least eight hours on day 1 and day 2. Significantly more cats in the treatment group were classified as having returned to normal on day 5, day 6 and day 7 compared with the placebo group. In the ovariohysterectomy trial, scores for behaviour (on day 1, day 2 and day 3) and appetite (on day 1 and day 2) were significantly better in the Vedaprofen group than in the placebo-treated cats. Clinical significance: Vedaprofen produced a clinically relevant reduction in body temperature and a more rapid return to normality in cats with upper respiratory tract disease. Vedaprofen treatment also resulted in more rapid recovery, presumably through the relief of pain and inflammation, in cats that had undergone soft tissue surgery.

A pharmacodynamic and pharmacokinetic study with Vedaprofen in an equine model of acute nonimmune inflammation

J Vet Pharmacol Ther 1999 Apr;22(2):96-106.PMID:10372594DOI:10.1046/j.1365-2885.1999.00173.x.

The pharmacodynamics and enantioselective pharmacokinetics of Vedaprofen were studied in six ponies in a two period cross-over study, in which a mild acute inflammatory reaction was induced by carrageenan soaked sponges implanted subcutaneously in the neck. Vedaprofen, administered intravenously at a dosage of 1 mg/kg, produced significant and prolonged inhibition of ex vivo serum thromboxane B2 (TXB2) synthesis and short-lived inhibition of exudate prostaglandin E2 (PGE2) and TXB2 synthesis. Vedaprofen also partially inhibited oedematous swelling and leucocyte infiltration into exudate. Vedaprofen displayed enantioselective pharmacokinetics, plasma concentrations of the R(-) enantiomer exceeding those of S(+) Vedaprofen. The plasma concentration ratio, R:S, increased from 69:31 at 5 min to 96:4 at 3 h and plasma mean AUC values were 7524 and 1639 ng x h/mL, respectively. Volume of distribution was greater for S(+) Vedaprofen, whilst elimination half-life (t(1/2beta)) and mean residence time were greater for R(-) Vedaprofen. The penetration of Vedaprofen into inflammatory exudate was also enantioselective. For R(-) and S(+) Vedaprofen maximum concentration (Cmax) values were 2950 and 1534 ng/mL, respectively, and corresponding AUC values were 9755 and 4400 ng x h/mL. Vedaprofen was highly protein bound (greater than 99%) in both plasma and exudate. The significance of these data for the therapeutic use of Vedaprofen is discussed.

A comparison of pre and post-operative Vedaprofen with ketoprofen for pain control in dogs

BMC Vet Res 2015 Feb 7;11:24.PMID:25880775DOI:10.1186/s12917-015-0338-4.

Background: This prospective randomized blinded clinical study aimed to investigate the potential of Vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy. Results: Pain control was effective and rescue analgesia was not necessary in any group. Pain scores were not significantly different between groups. The respiratory rate and rectal temperature were decreased in all groups at extubation until 6 hours post-extubation compared to baseline. Cortisol and epinephrine levels were increased only at 0.5 hours after extubation in all groups compared to baseline. Conclusions: Vedaprofen did not present any preventive analgesic effect. Pre- and postoperative Vedaprofen were as effective as ketoprofen for postoperative pain control.

Comparison of Vedaprofen and meloxicam in dogs with musculoskeletal pain and inflammation

J Small Anim Pract 2002 May;43(5):208-12.PMID:12038853DOI:10.1111/j.1748-5827.2002.tb00059.x.

In this randomised, multicentre clinical study, dogs with musculoskeletal pain and inflammation were treated with either Vedaprofen or meloxicam administered orally at the recommended dose rates. Clinical examinations were carried out regularly and clinical severity scores assigned. In total, 214 cases (73 acute, 141 chronic) were evaluated. Treatment with Vedaprofen and meloxicam was continued for 14 and 17 days, respectively, in the acute cases, and 38 and 39 days in the chronic cases. NSAID treatment resulted in a significant improvement in clinical scores. The overall response to treatment ('responders') at the final clinical examination was 89 per cent and 87 per cent in the acute cases and 72 per cent and 65 per cent in the chronic cases in the Vedaprofen and meloxicam groups, respectively. Mild transient gastrointestinal signs were observed in both groups (11 per cent Vedaprofen, 12 per cent meloxicam). Adverse effects related to NSAIDs resulted in treatment cessation in 5 per cent of the dogs in each group. Vedaprofen and meloxicam were efficacious in, and well tolerated by, most of the dogs in the study.