Visnagin
(Synonyms: 齿阿米素) 目录号 : GC49168
A furanochromone with diverse biological activities
Cas No.:82-57-5
Sample solution is provided at 25 µL, 10mM.
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Visnagin is a polyketide synthase-derived furanochromone originally isolated from A. visnaga that has diverse biological activities.1,2,3,4,5 It inhibits the germination and growth of ryegrass (IC50s = 502 and 214 µM, respectively).2 Visnagin (100 µg/ml) is cytotoxic to, and induces apoptosis in, HT-144 melanoma cells.3 It reduces LPS-stimulated increases in the secretion of TNF-α, IL-1β, and IFN-γ in BV-2 microglial cells when used at concentrations of 50 and 100 µM.4 Visnagin (25 mg/kg) protects against cardiomyopathy induced by doxorubicin in mice.5
1.Abe, I.Engineering of plant polyketide biosynthesisChem. Pharm. Bull. (Tokyo)56(11)1505-1514(2008) 2.Travaini, M.L., Sosa, G.M., Ceccarelli, E.A., et al.Khellin and visnagin, furanochromones from Ammi visnaga (L.) Lam., as potential bioherbicidesJ. Agric. Food Chem.64(50)9475-9487(2016) 3.Aydo?mu?-ÖztÜrk, F., Jahan, H., Beyazit, N., et al.The anticancer activity of visnagin, isolated from Ammi visnaga L., against the human malignant melanoma cell lines, HT 144Mol. Biol. Rep.46(2)1709-1714(2019) 4.Lee, J.-K., Jung, J.-S., Park, S.-H., et al.Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cellsArch. Pharm. Res.33(11)1843-1850(2010) 5.Liu, Y., Asnani, A., Zou, L., et al.Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenaseSci. Transl. Med.6(266)266ra170(2014)
| Cas No. | 82-57-5 | SDF | |
| 别名 | 齿阿米素 | ||
| Canonical SMILES | O=C1C=C(C)OC2=C1C(OC)=C3C=COC3=C2 | ||
| 分子式 | C13H10O4 | 分子量 | 230.2 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.344 mL | 21.7202 mL | 43.4405 mL |
| 5 mM | 0.8688 mL | 4.344 mL | 8.6881 mL |
| 10 mM | 0.4344 mL | 2.172 mL | 4.344 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet