Vitamin K1-d7

Vitamin K1-d7 is intended for use as an internal standard for the quantification of vitamin K1 by GC- or LC-MS. Vitamin K1 is a fat-soluble, dietary nutrient that is essential for the synthesis of proteins important for blood-clotting, bone metabolism, and cell growth.1 It is found in the photosynthetic tissues of green, leafy plants, where it acts as an electron acceptor forming part of the electron transport chain of Photosystem I.2 Vitamin K1 also serves as a precursor to vitamin K2 and is reported to exhibit anticancer activity in various cell lines.3,4

|1. Plaza, S.M., and Lamson, D.W. Vitamin K2 in bone metabolism and osteoporosis. Altern. Med. Rev. 10(1), 24-35 (2005).|2. Santabarbara, S., Heathcote, P., and Evans, M.C.W. Modelling of the electron transfer reactions in Photosystem I by electron tunnelling theory: The phylloquinones bound to the PsaA and the PsaB reaction centre subunits of PS I are almost isoenergetic to the iron-sulfur cluster FX. Biochim. Biophys. Acta. 1708(3), 283-310 (2005).|3. Beulens, J.W.J., Booth, S.L., van den Heuvel, E.G.H.M., et al. The role of menaquinones (vitamin K2) in human health. Br. J. Nutr. 1-12 (2013).|4. Lamson, D.W., and Plaza, S.M. The anticancer effects of vitamin K. Altern. Med. Rev. 8(3), 303-318 (2003).