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WWL123 Sale

目录号 : GC15209

A selective inhibitor of ABHD6

WWL123 Chemical Structure

Cas No.:1338575-41-9

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1mg
¥570.00
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5mg
¥1,683.00
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10mg
¥2,855.00
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25mg
¥5,996.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

IC50: 0.43 μM

WWL123 is a brain-penetrant inhibitor of ABHD6.

The serine hydrolase a/b-hydrolase domain 6 (ABHD6) has been reported to hydrolyze the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors.

In vitro: WWL123 was identified as a brain-penetrant inhibitor of ABHD6 demonstrating over 10-fold selectivity for ABHD6 compared to a panel of about 35 other serine hydrolases [1].

In vivo: In previous study, mice were pretreated with either vehicle or WWL123, and then they were treated with 50 mg/kg PTZ. It was found that pretreatment with WWL123 could block seizure-related mortality, reduce the severity of seizure behaviors, reduce the number of GTC seizures per mouse, and reduce the frequency of myoclonic (MC) seizures as well. In addition, to test whether behavioral seizures exhibited by R6/2 mice are controlled by chronic blockade of the eCB signaling system, the authors treated mice with a daily injection of vehicle, SR1, or WWL123. Results showed that WWL123 blocked the incidence of spontaneous behavioral seizures in R6/2 mice and there was no effect on duration of spontaneous seizures in response to chronic SR1 treatment vehicle [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Bachovchin, D. A.,Ji, T.,Simon, G.M., et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proceedings of the National Academy of Sciences of the United States of America 107(49), 20941-20946 (2010).
[2] Naydenov, A. V.,Horne, E.A.,Cheah, C.S., et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83(2), 361-371 (2014).

Chemical Properties

Cas No. 1338575-41-9 SDF
化学名 N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-carbamic acid, 4'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
Canonical SMILES O=C(N)C1=CC=C(C2=CC(OC(N(C)CC3=CC=CC(C4=CC=CC=C4)=C3)=O)=CC=C2)C=C1
分子式 C28H24N2O3 分子量 436.5
溶解度 ≤1mg/ml in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.291 mL 11.4548 mL 22.9095 mL
5 mM 0.4582 mL 2.291 mL 4.5819 mL
10 mM 0.2291 mL 1.1455 mL 2.291 mL
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