Xanthine
(Synonyms: 黄嘌呤) 目录号 : GC33846
A purine base
Cas No.:69-89-6
Sample solution is provided at 25 µL, 10mM.
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Xanthine is a purine base and intermediate in the biosynthesis of uric acid .1,2 It is formed during mammalian purine catabolism in the liver via oxidation of hypoxanthine by xanthine oxidase (XO), which also oxidizes xanthine to produce uric acid.1,3 Xanthine is also formed from guanine, xanthosine, or hypoxanthine during purine catabolism in plants.4 It has been found in a variety of commercial foodstuffs, including beer yeast, mushrooms, vegetables, fish, and beef.5 Urinary xanthine levels are decreased in patients with primary gout.6 Xanthine has also been used in the synthesis of xanthine derivatives that have anticancer or anti-inflammatory activities in vitro.7
1.Dawson, J., and Walters, M.Uric acid and xanthine oxidase: Future therapeutic targets in the prevention of cardiovascular disease?Br. J. Clin. Pharmac.62(6)633-644(2006) 2.Wu, S., Jia, S., and Dong, X.Study on detection methods for xanthine in food and biological samplesInt. J. Curr. Res. Chem. Pharm. Sci.3(8)(2016) 3.Garcia-Gil, M., Camici, M., Allegrini, S., et al.Emerging role of purine metabolizing enzymes in brain function and tumorsInt. J. Mol. Sci.19(11)3598(2018) 4.Zrenner, R., Stitt, M., Sonnewald, U., et al.Pyrimidine and purine biosynthesis and degradation in plantsAnnu. Rev. Plant Biol.57805-836(2006) 5.Kaneko, K., Aoyagi, Y., Fukuuchi, T., et al.Total purine and purine base content of common foodstuffs for facilitating nutritional therapy for gout and hyperuricemiaBiol. Pharm. Bull.37(5)709-721(2014) 6.Puig, J.G., Mateos, F.A., Jiménez, M.L., et al.Renal excretion of hypoxanthine and xanthine in primary goutAm. J. Med.85(4)533-537(1988) 7.Singh, N., Shreshtha, A.K., Thakur, M.S., et al.Xanthine scaffold: Scope and potential in drug developmentHeliyon4(10)e00829(2018)
| Cas No. | 69-89-6 | SDF | |
| 别名 | 黄嘌呤 | ||
| Canonical SMILES | O=C(N1)NC2=C(N=CN2)C1=O | ||
| 分子式 | C5H4N4O2 | 分子量 | 152.11 |
| 溶解度 | 5 mg/mL in Water (ultrasonic and warming and adjust pH to 10 with 1M NaOH and heat to 60°C)；8 mg/mL in 1M NaOH (ultrasonic and adjust pH to 11 with NaOH) | 储存条件 | Store at 2-8°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.5742 mL | 32.8709 mL | 65.7419 mL |
| 5 mM | 1.3148 mL | 6.5742 mL | 13.1484 mL |
| 10 mM | 0.6574 mL | 3.2871 mL | 6.5742 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet