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Xylopine Sale

(Synonyms: 木番荔枝碱) 目录号 : GC64127

Xylopine 是一种阿朴啡生物碱,对癌细胞具有细胞毒活性。Xylopine 诱导氧化应激,导致癌细胞的 G2/M 细胞周期停滞和细胞凋亡 (apoptosis)。

Xylopine Chemical Structure

Cas No.:517-71-5

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1mg
¥2,250.00
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Sample solution is provided at 25 µL, 10mM.

Description

Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells[1].

Xylopine (3.5 μM-14 μM; 24-48 hours) displays potent cytotoxicity in a time- and does-depenpent manner[1].Xylopine (72 h) has cytotoxic activity, with IC50 values ranging from 6.4 to 26.6 μM in eight different cancer cell lines (MCF7, HCT116, HepG2, SCC-9, HSC-3, HL-60, K-562, and B16-F10)[1].Xylopine (3.5 μM-14 μM; 24-48 hours) causes cell cycle block at the phase G2/M, which is followed by internucleosomal DNA fragmentation[1].Xylopine (3.5 μM-14 μM; 24-48 hours) significantly increases the early and late apoptosis, induces mitochondrial depolarization, and increases caspase-3 activation[1].Xylopine also causes an increase in the production of reactive oxygen/nitrogen species (ROS/RNS), including hydrogen peroxide and nitric oxide, but not superoxide anion, and reduces glutathione levels are decreased in Xylopine-treated HCT116 cells[1].HCT116 cells[1]3.5 μM, 7 μM, and 14 μM 24 hours, 48 hoursInduced G2/M phase arrest.HCT116 cells[1]3.5 μM, 7 μM, and 14 μM 24 hours, 48 hoursSignificantly increased the early and late apoptosis.

[1]. Luciano de Souza Santos, et al. Xylopine Induces Oxidative Stress and Causes G 2/M Phase Arrest, Triggering Caspase-Mediated Apoptosis by p53-Independent Pathway in HCT116 Cells. Oxid Med Cell Longev. 2017;2017:7126872.

化学性质

Cas No. 517-71-5 SDF Download SDF
别名 木番荔枝碱
分子式 C18H17NO3 分子量 295.33
溶解度 储存条件 4°C, away from moisture and light
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1 mg 5 mg 10 mg
1 mM 3.386 mL 16.9302 mL 33.8604 mL
5 mM 0.6772 mL 3.386 mL 6.7721 mL
10 mM 0.3386 mL 1.693 mL 3.386 mL
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