Z-321
目录号 : GC31152
Z-321是一个脯氨酰内肽酶(PEP)抑制剂。
Cas No.:130849-58-0
Sample solution is provided at 25 µL, 10mM.
Z-321 is a prolylendopeptidase (PEP) inhibitor.
Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity[1].
[1]. Oosuka I, et al. Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. Jpn J Pharmacol. 2000 May;83(1):82-5.
Animal experiment: | Femal wistar rats (200 to 250 g) are used and housed under conditions of controlled temperature (23 to 26°C) and photoperiod (14: 10 h, light:dark). Fifty four rats are ovariectomized under ether anesthesia. Two weeks after ovariectomy, sexual behavioral tests are carried out before and after a treatment with Z-321 (100, 200 or 300 mg/kg). Another group of rats, 7 females are given 1 mL/kg of 10% gum arabic as control group[1]. |
References: [1]. Oosuka I, et al. Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. Jpn J Pharmacol. 2000 May;83(1):82-5. |
Cas No. | 130849-58-0 | SDF | |
Canonical SMILES | O=C([C@H]1N(C(CC2CC3=C(C=CC=C3)C2)=O)CSC1)N4CCCC4 | ||
分子式 | C19H24N2O2S | 分子量 | 344.47 |
溶解度 | DMSO: 250 mg/mL (725.75 mM) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
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1 mg | 5 mg | 10 mg |
1 mM | 2.903 mL | 14.5151 mL | 29.0301 mL |
5 mM | 0.5806 mL | 2.903 mL | 5.806 mL |
10 mM | 0.2903 mL | 1.4515 mL | 2.903 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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% DMSO % % Tween 80 % saline | ||||||||||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Quality Control & SDS
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- Purity: >99.50%
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