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Z-WEHD-FMK Sale

(Synonyms: N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯,Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)) 目录号 : GC12190

Z-WEHD-FMK 是一种有效的、细胞渗透性和不可逆的 caspase-1/5 抑制剂。 Z-WEHD-FMK 还表现出对组织蛋白酶 B 活性的强大抑制作用 (IC50=6 μM)。 Z-WEHD-FMK 可用于研究细胞凋亡的证据。

Z-WEHD-FMK Chemical Structure

Cas No.:210345-00-9

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥4,914.00
现货
5mg
¥4,050.00
现货
10mg
¥5,850.00
现货
50mg
¥17,550.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Treatment of infected cells with pan-caspase inhibitor IV and Z-WEHD-FMK, an inhibitor of inflammatory caspases, elicited a near-complete blockage of C. trachomatis-induced cleavage of golgin-84. Golgin-84 cleavage was blocked via treatment of infected cells with Z-WEHD-FMK, resulting in a lack of Golgi fragmentation and a 2-log reduction in numbers of infectious bacteria.

We treated infected cells with Z-WEHD-FMK, effectively preventing Golgi fragmentation, or with DMSO as a control and then labelled cells with fluorescent ceramide. Confocal images revealed that ceramide was rapidly incorporated into the inclusion membrane within DMSO-treated cells and accumulated inside the inclusion in bacterial membranes. In contrast, Z-WEHD-FMK-treated cells were only slightly fluorescent as the majority of lipid accumulated in a Golgi-like structure outside the inclusion1.

General caspase inhibitor (Z-Asp-CHz-DCB) and capase-5 inhibitor (Z-WEHD-FMK) could not induce rRNA fragmentation treated with ECyd. Caspase-5 (ICErei Ill/TY), member of ICE protease, activated pathway may be concerned with ECyd induced rRNA fragmentation2.

References:
1. D. Heuer, A.R. Lipinski et al. Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction. NATURE, 457, 2009
2. Kamada, S., Funahashi, Y. and Tsujimoto, Y.(1997) Cell Death Diff. 4, 473-478.

Chemical Properties

Cas No. 210345-00-9 SDF
别名 N-[苄氧羰基]-L-色氨酰-L-ALPHA-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-组胺酰胺甲基酯,Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
化学名 methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoate
Canonical SMILES COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4
分子式 C37H42FN7O11 分子量 763.78
溶解度 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.3093 mL 6.5464 mL 13.0928 mL
5 mM 0.2619 mL 1.3093 mL 2.6186 mL
10 mM 0.1309 mL 0.6546 mL 1.3093 mL
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