Zearalanone
(Synonyms: 玉米赤霉酮) 目录号 : GC10684
A mycotoxin with estrogen-like effects
Cas No.:5975-78-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Zearalanone (ZAN) is an estrogen receptor agonist and also an androgen receptor antagonist [1].
Zearalenone (ZEN), a β-resorcyclic acid lactone (RAL), is a non-steroidal estrogenic mycotoxin biosynthesized by several Fusarium species. Zearalenone (ZEN) is the well-known mycotoxin present in numerous agricultural products [1][2][3][4]. In the human endometrial Ishikawa cell line, zearalenone (ZEN) exhibited strong oestrogenicity [4].When incubated Fusarium semitectum on sorghum, the ratio of ZAN to ZEN remained constant after 5 days, suggesting that ZAN might not be suitable for use as an internal standard [5].
Zearalanone, a major phase I metabolite of zearalenone (ZEN), is an estrogen receptor agonist and also an androgen receptor antagonist. In MCF-7 cells, Zearalanone strongly induced cell proliferation with EC50 value of 1.21 nM and showed significant estrogenic activity. Zearalanone behaved as full hERα agonist. In PALM cells, Zearalanone acted as a hAR antagonist that strongly inhibited the luciferase activity induced by 0.3 nM of R1881, the synthetic androgen [1].
References:
[1]. Molina-Molina JM, Real M, Jimenez-Diaz I, et al. Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. Food Chem Toxicol.2014 Dec;74:233-9.
[2]. Baldwin RS, Williams RD, Terry MK. Zeranol: a review of the metabolism, toxicology, and analytical methods for detection of tissue residues. Regul Toxicol Pharmacol. 1983 Mar;3(1):9-25.
[3]. Migdalof BH, Dugger HA, Heider JG, et al. Biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. Xenobiotica. 1983 Apr;13(4):209-21.
[4]. Le Guevel R, Pakdel F. Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. Hum Reprod. 2001 May;16(5):1030-6.
[5]. Aoyama K, Ishikuro E, Noriduki H, et al. Formation Ratios of Zearalanone, Zearalenols, and Zearalanols versus Zearalenone during Incubation of Fusarium semitectum on Sorghum and Ratios in Naturally Contaminated Sorghum. Shokuhin Eiseigaku Zasshi. 2015;56(6):247-51.
| Cas No. | 5975-78-0 | SDF | |
| 别名 | 玉米赤霉酮 | ||
| 化学名 | (3S)-3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione | ||
| Canonical SMILES | OC1=C(C(O[C@@H](C)CCCC(CCCCC2)=O)=O)C2=CC(O)=C1 | ||
| 分子式 | C18H24O5 | 分子量 | 320.4 |
| 溶解度 | DMSO : 100 mg/mL (312.13 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1211 mL | 15.6055 mL | 31.211 mL |
| 5 mM | 0.6242 mL | 3.1211 mL | 6.2422 mL |
| 10 mM | 0.3121 mL | 1.5605 mL | 3.1211 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。