α-Zearalenol
(Synonyms: ALPHA-玉米赤霉烯醇) 目录号 : GC11734
A major hepatic metabolite of zearalenone
Cas No.:36455-72-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Zearalenone (ZEA) is a mycotoxin produced mainly by fungi in foods and feeds. It is frequently involved in reproductive disorders of farm animals and occasionally in hyperoestrogenic syndromes in humans. ZEA and its metabolites possess oestrogenic activity in cattle, pigs and sheep. However, oral or interperitoneal administration of ZEA is relatively low acute toxic in mice, rat and pig. ZEA transformed into two metabolites α-zearalenol (α-ZEA) and β-zearalenol (β-ZEA) in animals which are subsequently conjugated with glucuronic acid. Moreover, ZEA has also been shown to be hepatotoxic, haematotoxic, immunotoxic and genotoxic. α-Zearalenol is a major hepatic metabolite in rats of zearalenone which impacts mammalian reproduction and development [1].
In vitro: The binding characteristic of α-ZEA was less potent with estrogen receptors than the parent compound [2]. α-zearalenol showed pronounced effects on uterotropic activity [3]. α-ZEA inhibited normal sperm motility, but stimulated hyperactive motility in the remaining motile cells and simultaneously induced the acrosome reaction [4].
References:
[1]. Zinedine A, Soriano J M, Molto J C, et al. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin[J]. Food and chemical toxicology, 2007, 45(1): 1-18.
[2]. Kiang D T, Kennedy B J, Pathre S V, et al. Binding characteristics of zearalenone analogs to estrogen receptors[J]. Cancer research, 1978, 38(11 Part 1): 3611-3615.
[3]. Mirocha C J, Pathre S V, Behrens J, et al. Uterotropic activity of cis and trans isomers of zearalenone and zearalenol[J]. Applied and environmental microbiology, 1978, 35(5): 986-987.
[4]. Filannino A, Stout T A E, Gadella B M, et al. Dose-response effects of estrogenic mycotoxins (zearalenone, alpha-and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion sperm[J]. Reproductive Biology and Endocrinology, 2011, 9(1): 134.
| Cas No. | 36455-72-8 | SDF | |
| 别名 | ALPHA-玉米赤霉烯醇 | ||
| 化学名 | (3S,7R,11E)-3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one | ||
| Canonical SMILES | OC1=C(C(O[C@@H](C)CCC[C@H](O)CCC/C=C/2)=O)C2=CC(O)=C1 | ||
| 分子式 | C18H24O5 | 分子量 | 320.4 |
| 溶解度 | ≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1211 mL | 15.6055 mL | 31.211 mL |
| 5 mM | 0.6242 mL | 3.1211 mL | 6.2422 mL |
| 10 mM | 0.3121 mL | 1.5605 mL | 3.1211 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。