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Ziconotide (trifluoroacetate salt) Sale

(Synonyms: ωConotoxin MVIIA, SNX-111) 目录号 : GC45180

A synthetic peptide blocker of N-type calcium channels

Ziconotide (trifluoroacetate salt) Chemical Structure

Cas No.:1660960-77-9

规格 价格 库存 购买数量
500μg
¥3,409.00
现货
1mg
¥5,122.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Ziconotide is a synthetic version of ω-conopeptide MVIIA, a peptide toxin originally found in the venom of the fish-eating marine snail C. magus, that blocks N-type calcium channels in rat brain membranes (Kds = 1.1-18 pM; IC50s = 2-55 pM)., It blocks high-voltage-activated calcium currents in rat superior cervical ganglion neurons (IC50 = 32 nM) as well as depolarization-induced norepinephrine release by rat peripheral sympathetic efferent neurons and in rat hippocampus (IC50s = 1.2 and 5.5 nM, respectively). Intrathecal administration of ziconotide inhibits formalin-induced flinch responses and increases the paw withdrawal threshold in the paw pressure test in rats (ED50s = 0.11 and 0.60 μg, respectively), indicating antinociceptive effects. It decreases latency to tail withdrawal in a hot plate test in a rat model of sciatic chronic constriction injury. Ziconotide also reduces infarct volume post ischemia in a rat model of transient focal ischemia.

Chemical Properties

Cas No. 1660960-77-9 SDF
别名 ωConotoxin MVIIA, SNX-111
分子式 C102H172N36O32S7•XCF3COOH 分子量 2639.1
溶解度 Water: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.3789 mL 1.8946 mL 3.7892 mL
5 mM 0.0758 mL 0.3789 mL 0.7578 mL
10 mM 0.0379 mL 0.1895 mL 0.3789 mL
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