Zilpaterol (hydrochloride)
(Synonyms: 盐酸齐帕特罗) 目录号 : GC48268
A β-adrenergic agonist
Cas No.:119520-06-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Zilpaterol is a β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues.1,2 It was approved by the FDA in 2006 as a veterinary food additive for the purpose of increasing lean body weight and improving feed efficiency in commercial beef cattle.3
1.AvendaÑo-Reyes, L., Torres-RodrÍguez, V., Meraz-Murullo, F.J., et al.Effects of two β-adrenergic agonists on finishing performance, carcass characteristics, and meat quality of feedlot steersJ. Anim. Sci.84(12)3259-3265(2006) 2.Miller, E.K., Chung, K.Y., Hutcheson, J.P., et al.Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explantsJ. Anim. Sci.90(4)1317-1327(2012) 3.Delmore, R.J., Hodgen, J.M., and Johnson, B.J.Perspectives on the application of zilpaterol hydrochloride in the United States beef industryJ. Anim. Sci.88(8)2825-2828(2010)
| Cas No. | 119520-06-8 | SDF | |
| 别名 | 盐酸齐帕特罗 | ||
| Canonical SMILES | O=C1NC2=CC=CC3=C2N1CC[C@H](NC(C)C)[C@H]3O.Cl | ||
| 分子式 | C14H19N3O2.HCl | 分子量 | 297.8 |
| 溶解度 | DMF: 0.1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.358 mL | 16.7898 mL | 33.5796 mL |
| 5 mM | 0.6716 mL | 3.358 mL | 6.7159 mL |
| 10 mM | 0.3358 mL | 1.679 mL | 3.358 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dietary Zilpaterol hydrochloride. I. Feedlot performance and carcass traits of steers and heifers
J Anim Sci 2009 Apr;87(4):1374-83.PMID:19098247DOI:10.2527/jas.2008-1162.
Experiments were conducted at 3 US locations (CA, ID, and TX) to determine the effects of dietary Zilpaterol hydrochloride (Zilmax, Intervet Inc., Millsboro, DE) and duration of Zilpaterol feeding on performance and carcass merit of finishing steers and heifers. At each site, 160 steers and 160 heifers were stratified within sex by initial BW (study d -1) and assigned randomly within BW strata to 1 of 4 treatments in a randomized complete block design (4 blocks/treatment for each sex). The 4 treatments were arranged in a 2 (no Zilpaterol vs. Zilpaterol) x 2 (20 or 40 d duration of Zilpaterol feeding) factorial arrangement of treatments. When included in the diet, Zilpaterol was supplemented at 8.3 mg/kg of DM. Each pen consisted of 10 animals. Each animal was individually weighed unshrunk on d 1, 21 or 41, and 66 of the experiment. Following d 66, cattle were slaughtered and carcass data collected. Feeding Zilpaterol increased (P<0.01) final BW of steers and heifers by 11.6 and 6.7 kg, respectively. In addition, feeding Zilpaterol hydrochloride increased (P
Perspectives on the application of Zilpaterol hydrochloride in the United States beef industry
J Anim Sci 2010 Aug;88(8):2825-8.PMID:20382871DOI:10.2527/jas.2009-2473.
Zilpaterol hydrochloride (ZH) is a beta-adrenergic agonist approved to be fed at a rate of 8.3 mg/kg (100% DM basis) during the final 20 to 40 d of the finishing period in beef cattle followed by a minimum 3-d withdrawal period antemortem. The Federal Drug Administration (FDA) approved label claims of increased rate of BW gain, improved feed efficiency, and increased carcass leanness. Before the release of ZH for commercial use in 2007, approximately 10 independent research trials at various universities and commercial feedlots were initiated. Articles in recent issues of the Journal of Animal Science are a result of the large comprehensive body of research designed to increase the understanding of the effect of ZH on beef cattle growth, carcass traits, and beef quality. The feeding of ZH for 20 to 40 d with a 3-d withdrawal resulted in significantly increased ADG. The increases equate to an average of 9 kg heavier BW in ZH-fed steers. Hot carcass weight has been shown to increase to a larger degree compared with BW, with an average improvement of 15 kg. Dressing percent is increased by 1.5 to 2.0% with the feeding of ZH. Increases in carcass leanness were reported for cattle fed ZH mainly through a reduction in yield grades. The LM area was increased, along with yield of subprimal cuts from the round, flank, and loin. Warner-Bratzler shear force studies have shown LM steaks from ZH-treated cattle to have increased shear force values of 1.1 to 1.7 kg for 7-d-aged steaks, 0.4 to 1.3 kg for 14-d-aged steaks, and 0.27 to 1.4 kg for 21-d-aged steaks compared with controls. Recent research has suggested that the aging response is normal in ZH steaks. Consumers were able to identify tenderness differences in 14-d-aged Choice steaks from cattle fed ZH for 20 d compared with 14-d-aged steaks from control cattle; this difference was mitigated with 21 d of postmortem aging. Zilpaterol hydrochloride has been shown to increase cattle growth and efficiency as well as lean tissue deposition in the carcass, with some impact on carcass traits such as Warner-Bratzler shear force.
Dietary Zilpaterol hydrochloride. II. Carcass composition and meat palatability of beef cattle
J Anim Sci 2009 Apr;87(4):1384-93.PMID:18849379DOI:10.2527/jas.2008-1168.
Experiments were conducted at 3 US locations (California, Idaho, and Texas) to determine the effects of dietary Zilpaterol hydrochloride and duration of Zilpaterol feeding on carcass composition and beef palatability. At each site, 160 steers and 160 heifers were stratified within sex by initial BW (study d -1) and assigned randomly within BW strata to 1 of 4 treatments in a randomized complete block design (4 blocks/treatment for each sex). The 4 treatments were arranged in a 2 (no Zilpaterol vs. Zilpaterol) x 2 (20- or 40-d duration of Zilpaterol feeding) factorial. When included in the diet, Zilpaterol was supplemented at 8.3 mg/kg (DM basis). Each pen consisted of 10 animals. After slaughter 2 carcasses per pen (n=64 per trial site) were selected. The entire right side of the selected carcasses was collected for dissection and chemical analysis of the soft tissue. Additionally, the left strip loin was collected for Warner-Bratzler shear force determinations and aged to 28 d postmortem. Sensory analysis was conducted on the Idaho trial site samples only. All data were pooled for analyses. Feeding Zilpaterol hydrochloride increased carcass muscle deposition (P<0.01) of both steer and heifer carcasses. However, carcass percentage fat of steers and heifers was not affected (P>0.11) by the Zilpaterol treatment. In heifer carcasses, carcass moisture percentage was increased (P=0.04) and bone percentage was decreased (P=0.02), whereas in steer carcasses, carcass moisture and bone percentage were not affected (P>0.10). In heifer carcasses, carcass ash percentage was not affected (P=0.61) by Zilpaterol, whereas in steer carcasses, carcass ash percentage tended (P=0.07) to be increased. The protein-to-bone ratio was increased (P<0.001) by Zilpaterol hydrochloride treatment in both steers and heifers, whereas the protein-to-fat ratio was not affected (P=0.10). Cooking loss of the LM was not affected (P=0.41) by Zilpaterol treatment of steers or heifers. However, LM Warner-Bratzler shear force was increased (P=0.003) on average (3.3 vs. 4.0 kg) due to Zilpaterol hydrochloride treatment of both steers and heifers. In both steers and heifers, LM sensory panel scores of overall juiciness (6.2 vs. 6.0), tenderness (6.2 vs. 6.0), and flavor intensity (6.2 vs. 6.0) tended (P=0.06) to be decreased in cattle supplemented with Zilpaterol. Zilpaterol hydrochloride is a repartitioning agent that seems to affect carcass composition primarily through protein deposition. However, Zilpaterol treatment can adversely affect tenderness and other palatability traits.
Effects of feeding Zilpaterol hydrochloride with and without monensin and tylosin on carcass cutability and meat palatability of beef steers
J Anim Sci 2009 Apr;87(4):1394-406.PMID:19028853DOI:10.2527/jas.2008-1170.
An experiment was conducted using 200 beef carcasses to evaluate the effects of feeding Zilpaterol hydrochloride with or without monensin and tylosin on carcass cutability and meat sensory variables. The experiment was conducted using a randomized complete block design with treatments arranged as a 2 (no Zilpaterol vs. Zilpaterol) x 2 (monensin and tylosin withdrawn vs. monensin and tylosin fed) factorial. Cattle (n=3,757) were fed Zilpaterol hydrochloride, a beta(2)-adrenergic agonist, for 30 d at the end of the finishing period and withdrawn from Zilpaterol hydrochloride for the last 5 d on feed. Five carcasses (weighing between 305 and 421 kg and free of slaughter defects) were selected from each of 40 feedlot treatment pens. Strip loins from the left sides were collected for sensory analysis and Warner-Bratzler shear force (WBSF) testing, and the rib was collected for 9th, 10th, 11th-rib dissections. A subsample of 3 carcass right sides per pen was fabricated into boneless subprimals according to Institutional Meat Purchase Specifications. Carcasses from zilpaterol-fed steers had greater (P
Effect of ractopamine hydrochloride and Zilpaterol hydrochloride on cardiac electrophysiologic and hematologic variables in finishing steers
J Am Vet Med Assoc 2016 Sep 15;249(6):668-77.PMID:27585105DOI:10.2460/javma.249.6.668.
OBJECTIVE To investigate the effects of dietary supplementation with the β-adrenoceptor agonists ractopamine hydrochloride and Zilpaterol hydrochloride on ECG and clinicopathologic variables of finishing beef steers. DESIGN Randomized controlled trial. ANIMALS 30 Angus steers. PROCEDURES Steers were grouped by body weight and randomly assigned to receive 1 of 3 diets for 23 days: a diet containing no additive (control diet) or a diet containing ractopamine hydrochloride (300 mg/steer/d) or Zilpaterol hydrochloride (8.3 mg/kg [3.8 mg/lb] of feed on a dry-matter basis), beginning on day 0. Steers were instrumented with an ambulatory ECG monitor on days -2, 6, 13, and 23, and continuous recordings were obtained for 72, 24, 24, and 96 hours, respectively. At the time of instrumentation, blood samples were obtained for CBC and serum biochemical and blood lactate analysis. Electrocardiographic recordings were evaluated for mean heart rate and arrhythmia rates. RESULTS Steers fed Zilpaterol or ractopamine had greater mean heart rates than those fed the control diet. Mean heart rates were within reference limits for all steers, with the exception of those in the ractopamine group on day 14, in which mean heart rate was high. No differences in arrhythmia rates were identified among the groups, nor were any differences identified when arrhythmias were classified as single, paired, or multiple (> 2) beats. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that dietary supplementation of cattle with ractopamine or Zilpaterol at FDA-approved doses had no effect on arrhythmia rates but caused an increase in heart rate that remained within reference limits.